Acetyl-P007

Ref. 3D-CRB1001658

Product Information

• Name: Acetyl-P007
• Synonyms: Ac-R(Ahx)RR(Ahx)RR(Ahx)RR(Ahx)R(Ahx)(bA)-OHAc-(RXR)4-X-B-acid, Where X is 6-aminohexanoic acid and where B is beta-alanineAc-(Arg- X-Arg)4-X-B-acid, Where X is 6-aminohexanoi c acid and where B is beta-alanine
• Brand: Biosynth
• Description: A range of opportunistic human pathogens can cause severe invasive infections. Organisms such as streptococci pyogenes and Acinetobacter baumannii have been effectively treated with antibiotics, but cases of antibiotic resistance are rising. A novel therapeutic strategy to combat human pathogens is the delivery of antisense peptide nucleic acids (PNAs) into bacteria that provide the antisense targeting of essential genes. PNA coupled to a cell-penetrating peptide (CPP) can effectively deliver the cargo into the cell. The CPP (RXR)4XB peptide (R, arginine- X, 6-aminohexanoic acid- B, β-alanine) conjugated to various cargo is highly effective at translocating PNA across the cell membrane. The efficiency of CPP-mediated PNA uptake is bacterial species-specific. For S. pyogenes, gyrA PNA coupled to (RXR)4XB abolished bacterial growth. For A. baumannii, the PNA cargo (BNANC-DNA) coupled to (RXR)4XB effectively inhibited translation and bacterial growth. This suggests that the CPP (RXR)4XB may be an effective tool in the future for combatting the rise in strains of antibiotic-resistant bacteria.

Chemical properties

• Molecular weight: 1,945.3 g/mol
• Purity: Min. 95%