SMAC/DIABLO [Lys(5-FAM)]

Ref. 3D-CRB1100325

Product Information

• Name: SMAC/DIABLO [Lys(5-FAM)]
• Synonyms: H-AVPIAQKSEK(5-FAM)-OHH-Ala-Val-Pro-Ile-Ala-Gln-Lys-Ser-Glu-Lys(5FAM)-OH
• Brand: Biosynth
• Description: SMAC/DIABLO [Lys(5-FAM)] is a pro-apoptotic peptide that is derived from the mitochondrial protein known either as Second Mitochondria-Derived Activator of Caspases (Smac) or Direct IAP Binding Protein with low isoelectric point, pI (DIABLO). During apoptosis the mitochondria has increased permeability to Smac/DIABLO, which causes the protein to diffuse into the cytosol. Here, Smac/DIABLO adheres to Inhibitors of apoptosis proteins (IAPs) and prevents them from binding to caspases, which in turn accentuates apoptosis.This peptide has a C-terminal lysine linker labelled with 5-Carboxyfluorescein (5-FAM), a widely used, green fluorescent tag.

Chemical properties

• Molecular weight: 1,428.54 g/mol
• Formula: C₆₈H₉₃N₁₃O₂₁
• Color/Form: Powder