![SMAC/DIABLO [Lys(5-FAM)]](https://static.cymitquimica.com/products/3D/img/CRB1100325.png "Click to enlarge")
SMAC/DIABLO [Lys(5-FAM)]
Ref. 3D-CRB1100325
| 1mg | 371.00 € | ||
| 500µg | 271.00 € |
Product Information
- AVPIAQKSE--acidH-Ala-Val-Pro-Ile-Ala-Gln-Lys-Ser-Glu--OH(N-Cbz-Nle-KRR)2-[R110]
- (N-Cbz-Nle-Lys-Arg-Arg)2-[Rh110]
SMAC/DIABLO [Lys(5-FAM)] is a pro-apoptotic peptide that is derived from the mitochondrial protein known either as Second Mitochondria-Derived Activator of Caspases (Smac) or Direct IAP Binding Protein with low isoelectric point, pI (DIABLO). During apoptosis the mitochondria has increased permeability to Smac/DIABLO, which causes the protein to diffuse into the cytosol. Here, Smac/DIABLO adheres to Inhibitors of apoptosis proteins (IAPs) and prevents them from binding to caspases, which in turn accentuates apoptosis.This peptide has a C-terminal lysine linker labelled with 5-Carboxyfluorescein (5-FAM), a widely used, green fluorescent tag.
Chemical properties
Technical inquiry about: 3D-CRB1100325 SMAC/DIABLO [Lys(5-FAM)]
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