(Tos-YASR)2-[Rh110]

Ref. 3D-CRB1100444

Product Information

• Name: (Tos-YASR)2-[Rh110]
• Synonyms: (Tos-YASR)2-[Rho-110]
• Brand: Biosynth
• Description: Optimal peptide substrate for kallikrein-related peptidase 14 (KLK14). In its intact state this peptide is not fluorescent, however when this substrate peptide is cleaved by KLK14, Rhodamine 110 is released and thus fluorescence can then be detected. This peptide therefore allows for the quantification of KLK14 peptidase activity. KLK14 is most abundant in the skin, with lower levels in breast and prostate and may form part of the protease cascade responsible for maintaining the epidermal barrier. Aberrant KLK14 proteolytic activity is linked to several skin pathologies. Overexpression of KLK14 seen in several hormone-dependent cancers, including prostate, colon, ovarian, and breast, correlating with higher risk of disease progression. Therefore KLK14 is a potential point of therapeutic intervention in a variety of pathologies.Contains rhodamine 110 group, a widely used red fluorescent tag. The terminal carboxylic acids in this peptide have been activated by the addition of the p-tosyl moiety, allowing for easy addition of functional groups or further peptide residues.

Chemical properties

• Molecular weight: 1,592.6 g/mol