[5-FAM]-GLP-1

Ref. 3D-CRB1100880

Product Information

• Name: [5-FAM]-GLP-1
• Synonyms: 5fam-HDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGR-NH2[5-FAM]-HDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGR-amide[5-FAM]-His-Asp-Glu-Phe-Glu-Arg-His -Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-T yr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2

Description

Glucagon-like peptide (GLP)-1 is a gastrointestinal peptide hormone with multiple roles in relation to metabolism. The primary role of GLP-1 is increasing insulin secretion in the presence of high plasma glucose levels, in addition, GLP-1 also suppresses glucagon secretion from the pancreas. GLP-1 slows down gastric emptying and regulates appetite, both valuable in reducing food intake and body weight. These roles of GLP-1 make it a useful target in the management of type 2 diabetes mellitus (T2DM).GLP-1 exerts its effects by binding to and activating the class B G protein-coupled receptor (GPCR): GLP-1 receptor (GLP-1R). Receptor activation in turn activates signalling pathways which culminates in insulin secretion via CAMP and Ca2+ signalling.Recently evidence has increased for GLP-1 playing a cardio-protective role as well as regulating immune responses and even in kidney function. GLP-1 may also exert neuroprotective and neurotropic effects as it can decrease endogenous levels of amyloid-β (Aβ) and prevent Aβ-induced cell death.This peptide contains N-terminal 5-Carboxyfluorescein (5-FAM), a widely used green fluorescent tag.

• Brand: Biosynth

Chemical properties

• Molecular weight: 4,467.1 g/mol
• Purity: Min. 95%
• Color/Form: Powder