Acetyl-α-2-antiplasmin-[AF680]

Ref. 3D-CRB1110405

Product Information

• Name: Acetyl-α-2-antiplasmin-[AF680]
• Synonyms: Ac-GNQEQVSPLTLLKW(C/AF680)-NH2Acetyl-GNQEQVSPLTLLK-W-C-[AF680]-amideAcetyl-Gly-Asn-Gln-Glu-Gln-Val-Ser-Pro-Leu-Thr-Leu-Leu-Lys-Trp -Cys-[AF680]-NH2Acetyl- Alpha- 2-antiplasmin-[AF680]
• Brand: Biosynth
• Description: Alpha-2-antiplasmin (alpha2AP), a member of the serine protease inhibitor (SERPIN) superfamily, is the main inhibitor of the fibrinolytic enzyme plasmin as well as an inhibitor of trypsin, elastase, and C protein. It plays a crucial role in reducing plasmin production and activity and thus inhibiting fibrinolysis.alpha2AP is synthesized in the liver and secreted as a single-chain glycoprotein, containing 11-14% carbohydrate, with a methionine (Met) as its N-terminus (Met-alpha2AP). The N-terminus of alpha2AP is involved in the incorporation of alpha2AP into a clot and the C-terminus is involved in the initial interaction of alpha2AP with plasmin(ogen). Circulating alpha2AP undergoes both N-and C-terminal modifications, which alter its activity. Increased concentrations of a2AP are associated with a higher risk of cardiovascular diseases.

Chemical properties

• Molecular weight: 2,735.2 g/mol
• Purity: Min. 95%