Neurokinin B Heavy

Ref. 3D-CRB1300292

Product Information

• Name: Neurokinin B Heavy
• Synonyms: H-DMHDFFVGL^M-NH2
• Brand: Biosynth
• Description: Neurokinin B (NKB) is a member of the tachykinin family of peptides that include substance P (SP), neurokinin A (NKA), endokinins and hemokinins. NKB is encoded by-TAC3-in humans and-Tac2-in rodents and along with the neuropeptide kisspeptin plays an essential role as gatekeeper of puberty.NKB plays a stimulatory role in luteinising hormone (LH) release in a number of species, likely mediated via the secretion of gonadotropin-releasing hormone (GnRH) in a kisspeptin-dependent manner (NKB appears to play a critical role in the control of kisspeptin release). NKB may contribute to the regulation of the reproductive function by metabolic cues. NKB binds with highest affinity to the G-protein coupled neurokinin-3 receptor NK3R- also known as tachykinin receptor 3 (TACR3).The leucine residue at position 9 of this peptide is isotopically labelled with carbon-13 (6) and nitrogen-15 (1), giving this peptide a mass increase of 7 compared to the unlabelled peptide.

Chemical properties

• Molecular weight: 1,216.5 g/mol
• Purity: Min. 95%