LL-24-29 Heavy

Ref. 3D-CRB1300681

Product Information

• Name: LL-24-29 Heavy
• Synonyms: H-IKDFLR^-OH
• Brand: Biosynth
• Description: A tryptic peptide consisting of residues 24-29 of the LL-37 peptide. The arginine residue at position 6 of this peptide is isotopically labelled with carbon-13 (6) and nitrogen-15 (4), giving this peptide a mass increase of 10 compared to the unlabelled peptide. This peptide can be used for quantification and optimisation in LC-MS/MS assays.LL-37 is a member of the large cationic family of anti-microbial peptides called cathelicidins which have broad-spectrum anti-microbial activity and are expressed in many species. The only cathelicidin found in humans is LL-37- this is produced in epithelial cells, by proteolytic cleavage from the C-terminal of the hCAP-18 protein. LL-37 can be processed into different forms of anti-microbial peptides. As well as its anti-microbial properties LL-37 also has anti-cancer properties and regulates many aspects of the innate immune system. Overexpression of LL-37 has been linked to autoimmune diseases such as asthma and psoriasis making LL-37 the most studied form of the human cathelicidin peptides.

Chemical properties

• Molecular weight: 800.5 g/mol
• Purity: Min. 95%