Oxyntomodulin Heavy
Ref. 3D-CRB1300756
| 25nMol | 452.00 € |
Product Information
- H-HSQGTFTSDYSKYL^DSRRAQDF^VQWL^MNTKRNRNNIA-OHHSQGTFTSDYSKY-[U-13C6,15N-Leu]-DSRRAQD-[U-13C9,15N-Phe]-VQW-[U-13C6,15N-Leu]-MNTKRNRNN IA-acidH-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-T yr-Ser-Lys-Tyr-[U-13C6,15N-Leu]-Asp-Ser-Arg-Arg-Ala-Gln-Asp-[U-13C9,15N-Phe
Oxyntomodulin is a glucose- and appetite-regulating gut hormone which may work with GLP-1 in the regulation of glucose metabolism and appetite in humans. Secretion of oxyntomodulin is significantly impaired in patients with type 2 diabetes, suggesting it may contribute to the pleiotropic pathophysiology of the disease.Oxyntomodulin is the 29 amino acids of glucagon with an additional C-terminal octapeptide tail. It is produced from proglucagon precursor peptide, along with glucagon-like peptide-1 (GLP-1), glucagon and glucagon-like peptide-2 (GLP-2). Oxyntomodulin activates both the human glucagon receptor and GLP-1 receptor, albeit with reduced efficacy compared to the native peptides. Oxyntomodulin reduces food intake via activity at the GLP-1 receptor, while its activity at the glucagon receptor causes weight loss by increasing energy expenditure.Oxyntomodulin levels are increased by more than 10-fold after gastric bypass surgery, therefore oxyntomodulin analogues many offer novel treatments for obesity. Chronic oxyntomodulin administration improves glucose tolerance by increasing insulin secretion via the GLP-1 receptor and by reducing weight.The leucine residues at position 14 and 26 and the phenylalanine residue at position 22 of this peptide are isotopically labelled with carbon-13 (6) and nitrogen-15 (1) giving this peptide a mass increase of 24 compared to the unlabelled peptide.
Chemical properties
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