Ubiquitin K63 Heavy

Ref. 3D-CRB1300818

Product Information

• Name: Ubiquitin K63 Heavy
• Synonyms: H-TLSDYNIQ(K/H-GG)ESTLHLVLR^-OHTLSDYNIQ-[K(GG)]-ESTLHLVL-[U-13C6,15N4-Arg]-acidH-Thr-Leu-Ser-Asp-Tyr-Asn-Ile-Gln-[Lys-(Gly-Gly)]-G lu-Ser-Thr-Leu-His-Leu-Val-Leu-[ U-13C6,15N4-Arg]-acid
• Brand: Biosynth
• Description: This sequence corresponds to the peptide bond between mammalian Lys63- (K63) linked Ub proteins- where (GG) corresponds to the C-terminus of the side chain appended Ub.K63-linked chains are the second most abundant linkage types found in cells and are modified with Met1-linked chains in mixed or branched architectures. K63-linked chains have a variety of non-degradative roles including- roles in intracellular trafficking, kinase signalling, DNA damage response, inflammatory signalling and NF-KB activation, however they may also be involved in some proteosome dependent pathwaysThe N-terminal arginine residue of this peptide is isotopically labelled with carbon-13 (6) and nitrogen-15 (4), giving this peptide a mass increase of 10 compared to the unlabelled peptide.

Chemical properties

• Molecular weight: 2,253.2 g/mol
• Purity: Min. 95%