Coagulation factor XI (FA11) (274-284) Heavy
Ref. 3D-CRB1300898
| 25nMol | 452.00 € |
Product Information
- H-AL^SGFSL^QS(Cam)R-OHA-[U-13C6,15N-Leu]-SGFS-[U-13C6,15N-Leu]-QS-[C(Cam)]-R-acidH-Ala-[U-13C6,15N-Leu]-Ser-Gly-Phe-Ser-[U-13C6,15 N-Leu]-Gln-Ser-[Cys(Cam )]-Arg-OH
Coagulation factor XI is an inactive protein precursor of the coagulation protease factor XIa, a major component of coagulation in the clotting cascade. Structurally factor XI is a disulfide dimer in which each subunit is made up of apple domains which are 90 or 91 amino acid repeats. At the C-terminus a catalytic domain is present. Within the blood it is found to be in complex with kininogen.Factor XI needs to be activated by either factor XIIa, α-thrombin, meizothrombin and factor XIa autoactivation through cleavage of factor XI Arg369-Ile370 bond. This produces active coagulation protease factor XIa, necessary for thrombin generation in the clotting cascade.The clotting cascade occurs in response to a vascular injury to reduce the amount of blood flow to the site of injury. It can be activated through the tissue factor pathway or the contact pathway.A deficiency in factor XI can contribute to bleeding disorders and can be the result of mutations on the FXI gene. Such mutations can include: Glu117Stop which results in the formation of a truncated protein and the missense mutation Phe283Leu effecting FXI dimer formation.
Chemical properties
Technical inquiry about: 3D-CRB1300898 Coagulation factor XI (FA11) (274-284) Heavy
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