PYY (1-36) Heavy
Ref. 3D-CRB1300937
| 25nMol | 452.00 € |
Product Information
- H-YPIKPEAPGEDASPEEL^NRYYASL^RHYL^NLVTRQRY-NH2YPIKPEAPGEDASPEE-[U-13C6,15N-Leu]-NRYYAS-[U-13C6,15N-Leu]-RHY-[U-13C6,15N-Leu]-NLVTRQR Y-amideH-Tyr-Pro-Ile-Lys-Pro-Glu-Ala-Pro-
Peptide YY is predominantly produced in the lower gastrointestinal tract from endocrine L cells but is also produced to a lesser extent by the enteric neurons of the stomach and pancreatic endocrine cells. Peptide YY is thought to be a satiety signal, acting to reduce food intake. In rodents, PYY-positive neurons have been identified in the hypothalamus, pons, medulla and spinal cord.Studies suggest that its expression is decreased under pro-inflammatory stimuli, and during the differentiation of monocytes to macrophages. PYY concentrations are also reduced in women with high dietary cognitive restraint (CR) as opposed to women with normal CR. This peptide is altered in various gastrointestinal disorders, and might be one of the causes of chronic idiopathic slow transit constipation (CST). It might also be responsible for the symptoms of inflammatory bowel disease and gastroenteropathy due to long-standing diabetes. However, in some gastrointestinal disorder it might have a positive role, as in the case of systemic sclerosis, celiac disease, and post-intestinal resection state.
Chemical properties
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