CHKtide dual Heavy
Ref. 3D-CRB1300974
| 25nMol | 452.00 € |
Product Information
- H-KKKV^SRSGLYRSPSMPENL^NRPR-OHKKK-[U-13C5,15N-Val]-SRSGLYRSPSMPEN-[U-13C6,15N-Leu]-NRPR-acidH-Lys-Lys-Lys-[U-13C5,15N-Val]-Ser-Arg -Ser-Gly-Leu-Tyr-Arg-Ser-Pro-Se r-Met-Pro-Glu-Asn-[U-13C6,15N-Leu]-Asn-Arg-Pro-Arg-OH
CHKtide is a synthetic peptide substrate for checkpoint kinase 1 and 2 (CHK1/CHK2) as well as salt-inducible kinase (SIKs), for use in kinase assays. CHKtide has been derived from CDC25C which is phosphorylated by CHK1/CHK2 in one of the DNA repair pathways. SIKs are serine/threonine kinases that are part of a complex network that regulate sodium homeostasis and blood pressure.The valine residue at position 4 has been isotopically labelled with carbon-13(5) and nitrogen-15(1) and the leucine residue at position 19 has been isotopically labelled with carbon-13(6) and nitrogen-15(1). This isotopic labelling gives this peptide a mass increase of 13 compared to the unlabelled peptide.
Chemical properties
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