IgG2 heavy chain Heavy

Ref. 3D-CRB1301145

Product Information

• Name: IgG2 heavy chain Heavy
• Synonyms: H-VVSVLTVVHQDWLNGK^-OHVVSVLTVVHQDWLNG-[U-13C6,15N2-Lys]-acidH-Val-Val-Ser-Val-Leu-Thr-Val-Val-His-Gln-Asp-Trp-Leu-Asn-Gly-[U-13C6, 15N2-Lys]-OH
• Brand: Biosynth
• Description: Peptide derived from the heavy chain of immunoglobulin G2 (IgG2). Ig or antibodies are made up of two heavy and two light chains both of which have a constant region and a variable region. The variable region, the antigen binding site, is composed of three complementarity determining regions (CDRs) from the variable heavy chain and three CDRs from the variable light chains. The amino acid sequences of the variable region differ between each antibody allowing Ig to bind to specific antigens.The Ig heavy chain can be classed as being either: IgM, IgG, IgA, IgD or IgE each of which change the function of the antibody. Furthermore IgG can be classed as either IgG1, IgG2, IgG3 or IgA2 and again each class exerts a different functional antibody.Class-switching to the IgG2 class usually occurs in response to bacterial capsular polysaccharide antigens. Consequently during IgG2 deficiency there is an increased risk of bacterial infections.The lysine residue is isotopically labelled at position 16 with carbon-13(6) and nitrogen-15(2).

Chemical properties

• Molecular weight: 1,801 g/mol
• Purity: Min. 95%