IgG1 heavy chain Heavy

Ref. 3D-CRB1301148

Product Information

• Name: IgG1 heavy chain Heavy
• Synonyms: H-VNSAAFPAPIEK^-OH
• Brand: Biosynth
• Description: Peptide derived from the heavy chain of immunoglobulin G1 (IgG1). Ig or antibodies are made up of two heavy and two light chains both of which have a constant region and a variable region. The variable region, the antigen binding site, is composed of three complementarity determining regions (CDRs) from the variable heavy chain and three CDRs from the variable light chains. The amino acid sequences of the variable region differ between each antibody allowing Ig to bind to specific antigens.The Ig heavy chain can be classed as being either: IgM, IgG, IgA, IgD or IgE each of which change the function of the antibody. Furthermore IgG can be classed as either IgG1, IgG2, IgG3 or IgA2 and again each class exerts a different functional antibody.The IgG1 class is induced by soluble protein antigens and due to it being the most abundant of the IgG subclasses, deficiencies in IgG1 cause overall levels of IgG to decrease. Consequently increasing the risk of recurring infections.The lysine residue is isotopically labelled at position 12 with carbon-13(6) and nitrogen-15(2).

Chemical properties

• Molecular weight: 1,250.7 g/mol
• Purity: Min. 95%