Complement component C9 Heavy
Ref. 3D-CRB1301341
| 25nMol | 452.00 € |
Product Information
- H-LSPIYNL^VPVK-OH
Complement component C9 is a fundamental factor of the complement system where several subunits of C9 form a complex with C5b, C6, C7 and C8 to generate the membrane attack complex (MAC). The MAC produces pores in the bacterial membrane thus causing a Ca2+ influx into the cell and bacterial cell death.C9 is a member of the Mac perforin-like superfamily. These all have a thrombospondin-1 domain, a low-density lipoprotein receptor-associated domain, a MACPF domain and an epidermal growth factor domain. Moreover C9 has the ability to form poly-C9 which can from structures similar to that of the MAC pore.Overall the main function of the complement system is to mark cells for phagocytosis, the recruitment of inflammatory cells and the cell lysis of bacteria cells by the MAC. The complement system as a whole can be associated with the neurological diseases, bacterial meningitis, thrombotic disorders, neurological and autoimmune diseases.The leucine residue at position 7 has been isotopically labelled with carbon-13 (6) and nitrogen-15 (1).
Chemical properties
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