Thymosin beta-4 Heavy
Ref. 3D-CRB1301342
| 25nMol | 452.00 € |
Product Information
- H-NPLP^SKETIEQEK^-OHNPL-[U-13C5,15N-Pro]-SKETIEQE-[U-13C6,15N2-Lys]-acidH-Asn-Pro-Leu-[U-13C5,15N-Pro]-Ser-Lys-Glu-Thr-Ile-Glu-Gln -Glu-[U-13C6,15N2-Lys ]-OH
Thymosin β-4 (TB4) is an actin binding proteins (ABP), encoded by the TMSB4X gene and is regarded as the principal actin-sequestering protein in many cell types. TB4 is involved in maintaining sufficient amounts of intracellular monomeric actin that is readily available for use if needed. TB4 works by binding monomeric G-actin rendering it resistant to polymerisation into F-actin. TB4 is present in all cells except red blood cells and is located both in the cytoplasm and nucleus of the cell.TB4 is also involved in cell proliferation, migration, differentiation and tissue regeneration and may contribute to repair of human heart muscle damaged by heart disease and heart attack. TB4 reduces levels of inflammatory mediators, lowers reactive oxygen species, and up-regulates anti-oxidative enzymes, anti-inflammatory genes, and anti-apoptotic enzymes.The proline residue at position 4 of this peptide and the lysine residue at position 13 of this peptide are isotopically labelled with carbon-13 and nitrogen-15, giving this peptide a mass increase of 14 compared to the unlabelled peptide.
Chemical properties
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