Glutathione peroxidase 3 Heavy

Ref. 3D-CRB1301346

Product Information

• Name: Glutathione peroxidase 3 Heavy
• Synonyms: H-NS(Cam)PPTSELL^GTSDR-OHNS-[Cys(Cam)]-PPTSEL-[U-13C6,15N-Leu]-GTSDR-acidH-Asn-Ser-[Cys(Cam)]-Pro-Pro-Thr-Ser-Glu-Leu-[U-13C6,15N- Leu]-Gly-Thr-Ser-Asp-Arg-O H
• Brand: Biosynth
• Description: Glutathione peroxidase-3 (GPx-3) is a plasma protein that scavenges reactive oxygen species (ROS) in the extracellular matrix (ECM). GPx-3 is a member of the selenocysteine-containing GPx family and accounts for nearly all the glutathione peroxidase activity in plasma.GPx-3 is highly expressed in the kidney and epididymis, but is also found localised to specific basement membranes in many tissues. The principal source of plasma GPx-3 is kidney proximal convoluted tubule (PCT) cells and the amount of Gpx3 in the kidney is greater than the amount circulating in the plasma. Deficiencies in GPx-3 impair the reductive metabolism of ROS, which leads to decreases in nitrous oxide (NO) bioavailability resulting in platelet-dependent thrombosis and stroke risk in young individuals. The Leucine residue at position 10 of this peptide is isotopically labelled with carbon-13 (6) and nitrogen-15 (1), giving this peptide a mass increase of 7 compared to the unlabelled peptide.

Chemical properties

• Molecular weight: 1,639.8 g/mol
• Purity: Min. 95%