Complement C5Heavy
Ref. 3D-CRB1301348
| 25nMol | 452.00 € |
Product Information
- H-DMQL^GR-OH
Complement C5 is a fundamental factor of the complement system pathways and whose cleavage by C5 convertase produces the anaphylatoxins C5a and C5b. This cleavage occurs due to the C3b factor binding to the C3 convertases from all the complement pathways: the classical, lectin and alternative and generating the C5 convertases C4bC2aC3b and C3bBbC3b.Overall the main functions of the complement system are to mark cells for phagocytosis, the recruitment of inflammatory cells and the cell lysis of bacteria cell by the MAC. The anaphylatoxins C3a and C5a recruit neutrophils and causes the inflammatory response while the MAC produces pores in the bacterial membrane thus causing a Ca2+ influx into the cell and bacterial cell death.Complement C5 is vital for the assembly of the MAC as C5b, the product of C5, in complex with C6 can bind to target cells. C5bC6 can then form a complex with C7, C8 and C9 to create the MAC, also known as C5b-9. The complement system as a whole can be associated with the neurological diseases, bacterial meningitis, thrombotic disorders, neurological and autoimmune diseases.The leucine residue at position 4 of complement C5 is isotopically labelled with carbon-13 (6) and nitrogen-14 (1).
Chemical properties
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