Anti-Ptgdr2 antibody - 0.5mg/mL
Ref. 3D-CRB2005684
| 20µg | 117.00 € |
Product Information
Prostaglandin D2 ligand activates G-protein-coupled receptors encoded by Ptgdr2, notably CRTh2, which mediate type 2 cytokine production, apoptosis inhibition and pro-inflammatory chemotaxis of Th2 cells, basophils and eosinophils, making the PGD2-CRTh2 pathway a vital factor in the regulation of allergic inflammation. Single nucleotide polymorphisms within the 3' UTR of the Ptgdr2 gene have been linked to asthma susceptibility, while Ptgdr2 signalling has been associated with self-renewal limitation of gastric cancer cells._x000D_
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The prostaglandin D and prostaglandin D2 receptor CRTh2 is a chemoattractant receptor homologue that, along with two of its known isoforms, belongs to the G-protein-coupled leukocyte chemoattractant receptor family. Under PGD2 ligation signals, CRTh2, D-prostanoid (DP1) and thromboxane prostanoid (TP) signals are thought to mediate the biological action of prostaglandin D2 through stimulating calcium release from intracellular stores.
Chemical properties
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