Anti-DYRK3 antibody - 2mg/mL

Ref. 3D-CRB2005740

Product Information

• Name: Anti-DYRK3 antibody - 2mg/mL
• Brand: Biosynth
• Description: Dual specificity tyrosine-phosphorylation-regulated kinase 3 (DYRK3) acts as a central dissolvase of membraneless organelles during the G2-to-M transition. DYRK3 mediates the phosphorylation of multiple serine and threonine residues in unstructured domains of proteins, including SRRM1 and PCM1._x000D_; _x000D_; DYRK3 is a key regulator of mTORC1 by mediating the dissolution of stress granules. During stressful conditions, DYRK3 partitions from the cytosol to the stress granule with mTORC1 components, which prevents mTORC1 signalling. When homeostasis is achieved, the kinase activity of DYRK3 is required for the dissolution of stress granule and mTORC1 relocation to the cytosol. DYRK3 mediates phosphorylation of signalling mTORC1 via inhibitor AKT1S1, allowing full reactivation of mTORC1 signalling._x000D_; _x000D_; DYRK3 is a negative regulator of EPO-dependent erythropoiesis and may place an upper limit on red cell production during stress erythropoiesis. DYRK3 also inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells._x000D_; _x000D_; Overexpression of DYRK3 has been linked to glioblastoma multiforme (GBM) and can be a strong predictive factor of a patient's survival chances.