Anti-Notch1 antibody - 2mg/mL

Ref. 3D-CRB2005747

Product Information

• Name: Anti-Notch1 antibody - 2mg/mL
• Brand: Biosynth
• Description: Notch1 is part of the Notch family, receptors involved in the Notch signalling pathway. Notch1 has the characteristic N-terminal EGF-like repeats and C-terminal LNR domains. Notch1 forms a complex with ligands to prevent signalling._x000D__x000D_The Notch signalling pathway is involved in cell fate specification, differentiation, proliferation, and survival processes. Activation of Notch1 is correlated with mammary tumorigenesis in mice. Increased expression of Notch receptors is linked to several cancer types, including cervical, colon, head and neck, lung, renal, pancreatic, leukaemia and breast cancer. Mutations directly affect survival rates in acute myeloid leukaemia. Notch inhibitors aim to downregulate the Notch signalling pathway. γ-secretase inhibitors block all Notch receptors, Notch1 short interference RNA, or Notch1 monoclonal antibodies specifically target Notch1. Notch1 inhibitors are a target to downregulate Notch signalling in breast cancer chemotherapy._x000D__x000D_Diseases associated with Notch1 are aortic valve disease 1 and Adams-Oliver syndrome 5.