AF488 Anti-mGluR1 antibody - 0.34mg/mL

Ref. 3D-CRB2115006

Product Information

• Name: AF488 Anti-mGluR1 antibody - 0.34mg/mL
• Synonyms: Alexa Fluor ® 488 Anti-mGluR1 antibody
• Brand: Biosynth
• Description: Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors that have been divided into three groups based on sequence, putative signal transduction mechanisms, and pharmacologic properties. mGluR1 is a group I receptor. Group I mGluRs are predominantly expressed in the postsynaptic somatodendritic regions, especially in brain areas highly responsive to psychostimulants. mGluR1 is a pivotal regulator of glutamatergic neurotransmission which is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions._x000D__x000D_Group I mGluRs are coupled exclusively to Gq protein (Gq/11), a heterotrimeric G protein subunit that activates phospholipase C (PLC) and regulates inositol 1,4,5-tris phosphate (IP3) receptors via association with the synaptic scaffolding protein, Homer._x000D__x000D_mGluRs modulate neuronal excitability and development, synaptic plasticity and neurotransmitter release underlying optimal cognitive function. Activation of mGluR1 facilitates long-term depression of parallel fiber-Purkinje cell synapses critical for cerebellar motor learning._x000D__x000D_This antibody is conjugated to Alexa Fluor® 488, a popular bright green fluorescent dye with high pH-stability.

Chemical properties

• Purity: Min. 95%