1,4-Dithiothreitol

CAS: 3483-12-3

Ref. 3D-D-8200

Product Information

• Name: 1,4-Dithiothreitol
• Synonyms: DL-threo-2,3-Dihydroxy-1,4-dithiobutane DL-threo-1,4-Dimercapto-2,3-butanediol rac-Cleland’s Reagent, (.+-.)-1,4-Dimercapto-2,3-butanediol, (.+-.)-Dithiothreitol, (2S,3S)-1,4-disulfanylbutane-2,3-diol, (R*,R*)-1,4-Dimercapto-2,3-butanediol, (R*,R*)-1,4-Dimercaptobutan-2,3-diol, (R*,R*)-1,4-Dimercaptobutane-2,3-diol, (R*,R*)-1,4-dimercaptobutano-2,3-diol, (R,R)-Dithiothreitol, 1,4-Dithio-<span class="text-smallcaps">DL</span>-threitol, 1,4-Dithio-DL-threitol, 1,4-Dithio-Dl-Threitol Sol., 1,4-Dithio-l-threitol, 2,3-Butanediol, 1,4-dimercapto-, (2R,3R)-rel-, 2,3-Butanediol, 1,4-dimercapto-, (R*,R*)-, 2,3-Butanediol, 1,4-dimercapto-, D-threo-, <span class="text-smallcaps">DL</span>-1,4-Dimercapto-2,3-dihydroxybutane, <span class="text-smallcaps">DL</span>-1,4-Dithiothreitol, <span class="text-smallcaps">DL</span>-Dithiothreitol, Cleland reagent, Cleland regent, Cleland's reagent, Clelands REDUCTACRYL, Clelands reagent, D-1,4-Dithiothreitol, D-Dtt, D-threo-1,4-Dimercapto-2,3-butanediol, DL-1,4-Dimercapto-2,3-dihydroxybutane, DL-1,4-Dithiothreitol, DL-Dithothreitol, DTT, DTT (threitol derivative), Dithiothreitol (Dtt) Sequencing Grade, Dithiothreitol Molecular Biology*Reagent, DithiothreitollelandsReagenz, Dithithreitol, L-Dtt, Mucolyse, Reagents, Cleland's, Sputolysin, Threitol, 1,4-dithio-, Wr 34678, rac-Dithiothreitol, rel-(2R,3R)-1,4-Dimercapto-2,3-butanediol, threo-1,4-Dimercapto-2,3-butanediol, threo-2,3-Dihydroxy-1,4-butanedithiol, threo-2,3-Dihydroxy-1,4-dithiolbutane

Description

Dithiothreitol, also known as DTT and Cleland’s reagent, is a broadly used disulfide reducing agent which finds application in the reduction of disulfide bridges in proteins. DTT is a fast, non-volatile solid and is less odorous than β-ME. DTT has a short half-life in water, requiring the preparation of fresh solutions every time. Furthermore, DTT must be used at neutral or basic pH due to the pKa values of the thiol moieties. DTT is a slightly more powerful reducing agent than its epimer DTE, due to the thiols trans to each other.

• Brand: Biosynth

Chemical properties

• Molecular weight: 154.25 g/mol
• Formula: C₄H₁₀O₂S₂