CAS 3483-12-3

Dithiothreitol

Description:

Dithiothreitol (DTT), with the CAS number 3483-12-3, is a small-molecule reducing agent commonly used in biochemistry and molecular biology. It is characterized by its ability to break disulfide bonds in proteins, thereby maintaining proteins in their reduced state. DTT is a colorless, crystalline solid that is soluble in water and has a relatively low molecular weight. Its chemical structure features two thiol (-SH) groups, which are responsible for its reducing properties. DTT is often employed in protein purification, enzyme assays, and studies involving protein folding and stability. It is important to note that DTT can be sensitive to oxidation, and its effectiveness can diminish over time when exposed to air. Additionally, while DTT is widely used, it can interfere with certain assays and should be used with caution in experiments involving sensitive reagents. Overall, DTT is a valuable tool in the study of protein chemistry and redox biology.

Formula: C₄H₁₀O₂S₂

InChI: InChI=1/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4-/s2

InChI key: InChIKey=VHJLVAABSRFDPM-SEFKMRKONA-N

SMILES: [C@H]([C@@H](CS)O)(CS)O

Synonyms:

• (.+-.)-1,4-Dimercapto-2,3-butanediol
• (.+-.)-Dithiothreitol
• (2S,3S)-1,4-disulfanylbutane-2,3-diol
• (R*,R*)-1,4-Dimercapto-2,3-butanediol
• (R*,R*)-1,4-Dimercaptobutan-2,3-diol
• (R*,R*)-1,4-Dimercaptobutane-2,3-diol
• (R*,R*)-1,4-dimercaptobutano-2,3-diol
• (R,R)-Dithiothreitol
• 1,4-Dithio-<span class="text-smallcaps">DL</span>-threitol
• 1,4-Dithio-DL-threitol
• 1,4-Dithio-Dl-Threitol Sol.
• 1,4-Dithio-l-threitol
• 1,4-Dithiothreitol
• 2,3-Butanediol, 1,4-dimercapto-, (2R,3R)-rel-
• 2,3-Butanediol, 1,4-dimercapto-, (R*,R*)-
• 2,3-Butanediol, 1,4-dimercapto-, D-threo-
• <span class="text-smallcaps">DL</span>-1,4-Dimercapto-2,3-dihydroxybutane
• <span class="text-smallcaps">DL</span>-1,4-Dithiothreitol
• <span class="text-smallcaps">DL</span>-Dithiothreitol
• Cleland reagent
• Cleland regent
• Cleland's reagent
• Clelands REDUCTACRYL
• Clelands reagent
• D-1,4-Dithiothreitol
• D-Dtt
• D-threo-1,4-Dimercapto-2,3-butanediol
• DL-1,4-Dimercapto-2,3-dihydroxybutane
• DL-1,4-Dithiothreitol
• DL-Dithothreitol
• DTT
• DTT (threitol derivative)
• Dithiothreitol (Dtt) Sequencing Grade
• Dithiothreitol Molecular Biology*Reagent
• DithiothreitollelandsReagenz
• Dithithreitol
• L-Dtt
• Mucolyse
• Reagents, Cleland's
• Sputolysin
• Threitol, 1,4-dithio-
• Wr 34678
• rac-Dithiothreitol
• rel-(2R,3R)-1,4-Dimercapto-2,3-butanediol
• threo-1,4-Dimercapto-2,3-butanediol
• threo-2,3-Dihydroxy-1,4-butanedithiol

1,4-Dithio-DL-threitol, Electrophoresis Grade, 99%

CAS: 3483-12-3

1,4-Dithio-DL-threitol is used as a protective agent for preventing oxidation of thiol groups and reagent for the reduction of disulfide groups in proteins. It is employed to investigate a-ketoglutarate dehydrogenase function, flavin cofactors in proteins and protein moieties involved in peroxide re

Formula: C₄H₁₀O₂S₂

Purity: 99%

Color and Shape: White, Powder

Molecular weight: 154.24

Ref: 02-J64545

1,4-Dithio-DL-threitol, 98%

CAS: 3483-12-3

Useful for stabilizing sulfhydryl-containing enzymes1,4-Dithio-DL-threitol is used as a protective agent in preventing oxidation of thiol groups and reagent for the reduction of disulfide groups in proteins. It is employed to investigate a-ketoglutarate dehydrogenase function, flavin cofactors in pr

Formula: C₄H₁₀O₂S₂

Purity: 98%

Color and Shape: White, Crystals or powder or crystalline powder

Molecular weight: 154.24

Ref: 02-A15797

Dithiothreitol, &gt;99.5%, Molecular Biology Grade, Ultrapure

CAS: 3483-12-3

Thermo Scientific Dithiothreitol Molecular Biology Grade Ultrapure Used as protective agent for SH groups

Formula: C₄H₁₀O₂S₂

Purity: 99.5%

Color and Shape: White crystalline powder

Molecular weight: 154.24

Ref: 02-J15397

1,4-Dithio-DL-threitol

CAS: 3483-12-3

Reagent for quantitative reduction of disulfide groups. Hygroscopic. DTT has been employed as substrate in combination with homovanillic acid in an continuous fluorescence assay for sulfhydryl oxidase. Former CAS-number: 27565-41-9.

Formula: C₄H₁₀O₂S₂

Purity: > 99%

Color and Shape: White

Molecular weight: 154.25

Ref: 01-4031235

DTT

CAS: 3483-12-3

DTT

Formula: C₄H₁₀O₂S₂

Purity: ≥95%

Molecular weight: 154.25

Ref: 54-BUP18636

DTT

CAS: 3483-12-3

cis-2,3-Dihydroxy-1,4-butanedithiol

Formula: C₄H₁₀O₂S₂

Purity: 95%

Molecular weight: 154.25

Ref: IN-DG127015

DTT for molecular biology

CAS: 3483-12-3

DTT for molecular biology

Formula: C₄H₁₀O₂S₂

Color and Shape: White Solid

Molecular weight: 154.251

Ref: 54-BIA2948

(+/-) Dithiothreitol molecular biology grade

CAS: 3483-12-3

(+/-) Dithiothreitol molecular biology grade

Formula: C₄H₁₀O₂S₂

Purity: >99%

Color and Shape: White Solid

Molecular weight: 154.25099

Ref: 54-BIMB1015

DL-1,4-Dithiothreitol

CAS: 3483-12-3

Formula: C₄H₁₀O₂S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 154.2510

Ref: IN-DA0034SI

DL-1,4-Dithiothreitol

CAS: 3483-12-3

DL-1,4-Dithiothreitol

Formula: C₄H₁₀O₂S₂

Purity: 98%

Color and Shape: Solid-Powder

Molecular weight: 154.253

Ref: 54-BI12118

DL-Dithiothreitol, 99%

CAS: 3483-12-3

Formula: C₄H₁₀O₂S₂

Purity: Dihydroxydithiane: ≤ 0.4%

Color and Shape: White to off-white powder

Molecular weight: 154.25

Ref: 7W-GC1199

DL-Dithiothreitol, 98%

CAS: 3483-12-3

Formula: C₄H₁₀O₂S₂

Purity: (Titration) 98.0 - 102.0 %

Color and Shape: White or almost white powder

Molecular weight: 154.25

Ref: 7W-GC3928

DL-Dithiothreitol

CAS: 3483-12-3

Formula: C₄H₁₀O₂S₂

Color and Shape: White To Off-White Solid

Molecular weight: 154.24

Ref: 4Z-D-196001

DL-Dithiothreitol

CAS: 27565-41-9, 3483-12-3

Formula: C₄H₁₀O₂S₂

Purity: >98.0%(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 154.24

Ref: 3B-D1071

DL-Dithiothreitol [for Electrophoresis]

CAS: 27565-41-9, 3483-12-3

Formula: C₄H₁₀O₂S₂

Purity: >98.0%(T)

Color and Shape: White powder to crystal

Molecular weight: 154.24

Ref: 3B-D3647

Dithiothreitol DTT

CAS: 3483-12-3

M02712 - Dithiothreitol DTT

Formula: C₄H₁₀O₂S₂

Purity: >99%

Color and Shape: Powder

Molecular weight: 154.24

Ref: 10-M02712

DTT

CAS: 3483-12-3

DTT (DL-Dithiothreitol) is a strong reducing agent. DTT has anti-disulfide ptosis activity. High-Quality, Low-Cost!

Formula: C₄H₁₀O₂S₂

Purity: 98.54% - ≥95%

Color and Shape: Solid

Molecular weight: 154.25

Ref: TM-T5370

rac Dithiothreitol

CAS: 3483-12-3

Applications Dithiothreitol is a redox reagent commonly used as a reducing agent for thiolated DNA. Dithiothreitol is also used to reduce the disulfide bonds of proteins.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lee, C.-Y. et al.: Langmuir, 21, 5134 (2005); Lu, B.-Y. et al.: Anal. Biochem., 405, 67 (405);

Formula: C₄H₁₀O₂S₂

Color and Shape: Neat

Molecular weight: 154.25

Ref: TR-D494285

1,4-Dithiothreitol

CAS: 3483-12-3

Dithiothreitol (DTT), also known as Cleland’s reagent, is a broadly used disulfide reducing agent which finds application in the reduction of disulfide bridges in proteins. DTT is a fast, non-volatile solid, less odorous than β-ME. DTT has a short half-life in water, requiring the preparation of fresh solutions every time. DTT must be used at neutral or basic pH due to the pKa values of the thiol moieties. DTT is a slightly more powerful reducing agent than its epimer DTE, thanks to the thiols trans to each other.

Formula: C₄H₁₀O₂S₂

Molecular weight: 154.25 g/mol

Ref: 3D-D-8201

Dithiothreitol

CAS: 3483-12-3

Dithiothreitol, also known as DTT and Cleland’s reagent, is a broadly used disulfide reducing agent which finds application in the reduction of disulfide bridges in proteins. DTT is a fast, non-volatile solid, less odorous than β-ME. DTT has a short half-life in water, requiring the preparation of fresh solutions every time. DTT must be used at neutral or basic pH due to the pKa values of the thiol moieties. DTT is a slightly more powerful reducing agent than its epimer DTE, thanks to the thiols trans to each other.

Formula: C₄H₁₀O₂S₂

Color and Shape: Powder

Molecular weight: 154.25 g/mol

Ref: 3D-FD02370