3-Hydroxy guanfacine

Ref. 3D-DDA19784

Product Information

• Name: 3-Hydroxy guanfacine
• Brand: Biosynth
• Description: Guanfacine is a drug that is used to treat high blood pressure, anxiety disorders, and attention-deficit hyperactivity disorder. It is an alpha2A receptor agonist and thus it has antihypertensive, antidepressant, and antipsychotic effects. Guanfacine can be metabolized through a number of metabolic transformations, including sulfation and glucuronidation. The methylation of guanfacine by catechol-O-methyltransferase (COMT) produces the active form of the drug, 3-hydroxy guanfacine. This active form can then be metabolized through monooxidation or enzymatic hydrolysis to produce metabolites that are more polar than the parent compound. Guanfacine is also an antagonist at postsynaptic alpha2B receptors and it has been shown to inhibit catecholamine synthesis in animals.; Guanfacine's chromatographic properties have been studied extensively and it has been shown to elute with other drugs

Chemical properties

• Molecular weight: 262.09 g/mol
• Formula: C₉H₉Cl₂N₃O₂
• Purity: Min. 95%