Product Information
Name:MDK74978
Brand:Biosynth
Description:MDK74978 is a small molecule that binds to the ATP-binding site of the HIF-1α kinase and inhibits its activity. It has been shown to inhibit the activity of other multi-kinase enzymes, such as PKCθ, Akt, and ERK1/2. MDK74978 has shown efficacy in animal models for treatment of iron overload disorders, such as hereditary hemochromatosis (HFE) and thalassemia major (HBA). In these models, MDK74978 improved iron homeostasis by increasing hepcidin synthesis in hepatocytes. This drug also showed efficacy in a mouse model with chronic kidney disease (CKD), which may be due to its ability to regulate erythropoietin production and enhance erythropoiesis.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:418.38 g/mol
Formula:C20H17F3N4O3
Purity:Min. 95%
Technical inquiry about: MDK74978
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