Product Information
- PF 6405761
- 2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide
- PFI 1
- Benzenesulfonamide, 2-methoxy-N-(1,2,3,4-tetrahydro-3-methyl-2-oxo-6-quinazolinyl)-
- 2-Methoxy-N-(1,2,3,4-tetrahydro-3-methyl-2-oxo-6-quinazolinyl)benzenesulfonamide
PFI-1 is a protein inhibitor that inhibits transcriptional regulation through the inhibition of histone acetylation. PFI-1 has been shown to inhibit the replication of HIV and influenza A virus in vitro. PFI-1 binds to the acetylated lysine residues on histones, preventing their acetylation by HDACs and inhibiting transcriptional regulation. The mechanism of action for PFI-1 is not well understood, but it has been shown to inhibit proliferation of prostate cancer cells and may be a potential therapeutic agent for treatment of autoimmune diseases.
Chemical properties
Technical inquiry about: 3D-DGC76472 PFI-1 (PF-6405761)
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