Product Information
JNJ-47965567 is a selective ligand of the α1 subunit of the non-selective cation channel, which is expressed in neurons and glial cells. JNJ-47965567 binds to this receptor with high affinity and potency. The binding of JNJ-47965567 to the α1 subunit induces a conformational change that blocks calcium uptake into the cell, leading to neuronal death. This compound has been shown to be efficacious in vitro against granule neurons from rats and mice deficient in the α1 subunit. In addition, JNJ-47965567 has anti-inflammatory effects on microglia cells derived from mice with experimental autoimmune encephalomyelitis (EAE) by inhibiting nitric oxide synthase activity.
JNJ-47965567 also has anticancer activities that are mediated by its ability to inhibit tumor growth and induce apoptosis in cancer cells in vitro.
Chemical properties
Technical inquiry about: 3D-DHC32731 JNJ-47965567
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