Product Information
Ibrutinib d5 is a potent and selective inhibitor of Bruton's tyrosine kinase (BTK). BTK is a non-receptor protein tyrosine kinase that plays an important role in the B-cell receptor signaling pathway. Ibrutinib d5 binds to BTK, and blocks its ATP binding site, preventing it from phosphorylating other proteins. This inhibition reduces the phosphorylation of key downstream effectors, such as ZAP-70, which is involved in B-cell proliferation and activation. Ibrutinib d5 also inhibits activation of PI3K/Akt signaling pathways and suppresses cytokine production.
Ibrutinib d5 has been shown to be effective for the treatment of chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). It can be used for research purposes as a tool for studying proteins involved in cell biology, peptides, pharmacology
Chemical properties
Technical inquiry about: 3D-DMC97717 Ibrutinib d5
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