Bis-(4-methylumbelliferyl)phosphate

CAS: 51379-07-8

Ref. 3D-EB15696

Product Information

• Name: Bis-(4-methylumbelliferyl)phosphate
• Synonyms: Bis-MUPBis(Mu)-phos, 2H-1-Benzopyran-2-one, 7,7'-(phosphinicobis(oxy))bis(4-methyl)-, 7,7'-(Phosphinicobis(oxy))bis(4-methyl-2H-1-benzopyran-2-one), bis(4-methyl-2-oxo-2H-chromen-7-yl) hydrogen phosphate

Description

Bis-(4-methylumbelliferyl)phosphate is a fluorescent analog of the substrate for phosphodiesterase. It is used in biochemical assays to measure the activity of phosphodiesterases, which are enzymes that catalyze the hydrolysis of phosphodiesters and are involved in many cellular processes, including neurotransmitter release, muscle contraction, and cell division. Bis-(4-methylumbelliferyl)phosphate is used to diagnose Gaucher's disease by demonstrating an increased rate of hydrolysis in patients with this condition. This chemical can also be used as a model system to study phosphatases and other enzymes that use phosphate groups as substrates.
Bis-(4-methylumbelliferyl)phosphate has been shown to inhibit the enzyme activities of some phosphatases by binding competitively to the active site of these enzymes. The optimum pH for bis-(4-methylumbelliferyl)phosphate is 8.

• Brand: Biosynth

Chemical properties

• Molecular weight: 414.3 g/mol
• Formula: C₂₀H₁₅O₈P
• Purity: Min. 95 Area-%
• Color/Form: White Powder
• InChI: InChI=1S/C20H15O8P/c1-11-7-19(21)25-17-9-13(3-5-15(11)17)27-29(23,24)28-14-4-6-16-12(2)8-20(22)26-18(16)10-14/h3-10H,1-2H3,(H,23,24)
• InChI key: InChIKey=FEGSOIMPQDYXJD-UHFFFAOYSA-N
• SMILES: Cc1cc(=O)oc2cc(OP(=O)(O)Oc3ccc4c(C)cc(=O)oc4c3)ccc12