4-Iodo-1-methyl-1h-pyrazole-5-carbonitrile
CAS: 1354705-14-8
Ref. 3D-EEC70514
| 50mg | 192.00 € | ||
| 500mg | 765.00 € |
Product Information
4-Iodo-1-methyl-1H-pyrazole-5-carbonitrile is a tetrazole molecule that has been shown to have potent and selective inhibitory activity against human PCSK9. This compound binds to the catalytic site of PCSK9 and prevents the formation of an active enzyme, therefore inhibiting the production of LDL cholesterol. 4-Iodo-1-methyl-1H-pyrazole-5-carbonitrile is a prodrug that is metabolized by acetaldehyde dehydrogenase to form an active inhibitor. The reaction proceeds in a chiral and enantioselective manner, which allows for the synthesis of racemic mixtures of this drug.
Chemical properties
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