TNP-470

CAS: 129298-91-5

Ref. 3D-EFA29891

Product Information

• Name: TNP-470
• Synonyms: (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]oct-6-yl (chloroacetyl)carbamate, 1-Oxaspiro[2.5]octane, carbamic acid deriv., 5-Methoxy-4-[2-Methyl-3-(3-Methylbut-2-En-1-Yl)Oxiran-2-Yl]-1-Oxaspiro[2.5]Oct-6-Yl (Chloroacetyl)Carbamate, Carbamic acid, (chloroacetyl)-, (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester, Carbamic acid, (chloroacetyl)-, 5-methoxy-4-[2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester, [3R-[3α,4α(2R*,3R*),5β,6β]]-, Carbamic acid, N-(2-chloroacetyl)-, (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester, Lodamin, NSC 642492, O-(Chloroacetylcarbamoyl)fumagillol, O-(chloroacetyl-carbamoyl) fumagillol, O-Chloroacetylcarbamoylfumagillol, Tnp 470, [(3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl] N-(2-chloroacetyl)carbamate, AGM 1470

Description

TNP-470 is a drug that inhibits angiogenesis by binding to and inhibiting the activity of the angiogenic protein vascular endothelial growth factor (VEGF). TNP-470 has been shown to block tumor-induced angiogenesis in mice. This drug also blocks tumor growth in human cancers, such as melanoma and colorectal cancer, by inhibiting VEGF. TNP-470 is an inhibitor of the polymerase chain reaction and is used as a model system for studying the molecular biology of angiogenesis. The drug has been shown to inhibit the activation of toll-like receptor 4 (TLR4) on endothelial cells which prevents TLR4 from activating proinflammatory cytokines, thereby preventing blood vessel formation.

• Brand: Biosynth

Chemical properties

• Molecular weight: 401.88 g/mol
• Formula: C₁₉H₂₈ClNO₆
• Purity: Min. 95%