Product Information
Name:N-tert-Butylpiperidine-2-carboxamide
Brand:Biosynth
Description:N-tert-Butylpiperidine-2-carboxamide is a small molecule that has been shown to bind to the cavity of the active site of human thiopurine S-methyltransferase (TPMT), blocking access by substrates and competitive inhibitors. It was synthesized as a peptidomimetic inhibitor for TPMT, which is an enzyme that catalyzes the methylation of thiopurines, such as 6-MP. The X-ray crystallographic studies revealed that N-tert-butylpiperidine-2-carboxamide is a homodimeric molecule with two binding sites on each monomer. The inhibition of TPMT by N-tert-butylpiperidine-2-carboxamide results in increased levels of 6MP and decreased levels of 6TG, leading to improved therapeutic outcomes when given with 6MP.
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Chemical properties
Molecular weight:184.28 g/mol
Formula:C10H20N2O
Purity:Min. 95%
Technical inquiry about: N-tert-Butylpiperidine-2-carboxamide
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