Product Information
Proteasome Inhibitor III (PI3) is a natural compound that has been shown to have cytotoxic activity against tumor cells. PI3 inhibits the protease activity of the 26S proteasome, which leads to the accumulation of oxidized proteins and DNA damage. PI3 also induces autophagy and mitophagy, which are cellular processes that help protect against oxidative injury. PI3 also interferes with signal pathways such as the p38/JNK pathway and the STAT-3 pathway, leading to increased levels of c-jun phosphorylation and colony-stimulating factor (CSF), respectively. PI3 is also able to inhibit k562 cells proliferation in vitro by blocking cell cycle progression at G2/M phase. The molecular pathogenesis of prostate cancer is not well understood; however, it may be due in part to increased levels of reactive oxygen species within mitochondria.
Chemical properties
Technical inquiry about: 3D-EHA32422 Proteasome Inhibitor III
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