Product Information
AP39 is a potent small molecule that acts as a mitochondrially-targeted hydrogen sulfide (H2S) donor exhibiting promising anticancer properties. Beyond its antitumor activity, AP39 demonstrates remarkable protective effects in renal oxidative injury and cardiomyopathy. The mechanism of action of AP39 appears to improve mitochondrial function, attenuate inflammation, and regulate mitophagy via the AMPK-ULK1-FUNDC1 pathway. Notably, AP39 prevents gastric mucosal damage and enhances cardiac function in doxorubicin-induced cardiotoxicity models. These pleiotropic effects makes AP39 to be a potential therapeutic candidate with broad applicability, and it could bring further studies for preclinical and clinical research.
Chemical properties
Technical inquiry about: 3D-EHC17357 AP39
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