4-Methylumbelliferyl 2-acetamido-2-deoxy-α-D-glucopyranoside-6-sulfate potassium

CAS: 210357-37-2

Ref. 3D-EM04850

Product Information

• Name: 4-Methylumbelliferyl 2-acetamido-2-deoxy-α-D-glucopyranoside-6-sulfate potassium
• Synonyms: 4MU-a-N-sulpho-D-glucosaminide potassium
• Brand: Biosynth
• Description: 4-Methylumbelliferyl 2-acetamido-2-deoxy-alpha-D-glucopyranoside-6-sulfate potassium is a fluorogenic substrate for N-acetylglucosamine-6-sulfatase. After enzymatic cleaveage, free 4-methylumbelliferone (also known as hymecromone) is released, exhibiting blue fluorescence upon excitation with UV light. The strongest fluorescence of 4-methylumbelliferone requires deprotonation of the hydroxyl group (thus requires alkaline pH), with a maximal fluorescence intensity obtained with excitation at 350 to 370 nm and emission at 440 to 470 nm. The use of 4-methylumbelliferyl 2-acetamido-2-deoxy-alpha-D-glucopyranoside-6-sulfate potassiumas a substrate for measuring the N-acetylglucosamine-6-sulfatase activity is used for screening of Mucopolysaccharidosis IIID (MPS IIID) (a rare lysosomal storage disorder) and Sanfilippo D syndrome diagnosis.

Chemical properties

• Molecular weight: 497.52 g/mol
• Formula: C₁₈H₂₀KNO₁₁S
• Purity: Min. 95%
• Color/Form: White Powder