4-Methylumbelliferyl 2-deoxy-2-sulfamino-a-D-glucopyranoside sodium salt - Moscerdam™ biochemical purity

CAS: 460085-45-4

Ref. 3D-EM06602

Product Information

• Name: 4-Methylumbelliferyl 2-deoxy-2-sulfamino-a-D-glucopyranoside sodium salt - Moscerdam™ biochemical purity
• Synonyms: 4-Methylumbelliferyl N-sulpho-a-D-glucosaminide.Na4-MU-GlcNSM3A4MU-a-N-sulpho-D-glucosaminide
• Brand: Biosynth
• Description: 4-Methylumbelliferyl 2-deoxy-2-sulfamino-a-D-glucopyranoside sodium salt (M3A or MU-GlcNS) is a fluorogenic substrate of heparin sulfamidase, used in the diagnosis of Mucopolysaccharidosis III type A (MPS III A). MPS III A, also known as Sanfilippo syndrome type A, is caused by the deficiency of heparan N-sulfatase. Heparin sulfamidase in the assay desulfates MU-GlcNS to 4-methylumbelliferyl 2-amino-2-deoxy-α-D-glucopyranoside (MU-GlcNH2). To release fluorometrically measurable 4-methylumbelliferone (MU) and by-product glucosamine, MU-GlcNH2 is further hydrolysed by an enzyme such as yeast α-glucosidase during a second incubation.

Chemical properties

• Molecular weight: 439.37 g/mol
• Formula: C₁₆H₁₈NO₁₀SNa
• Purity: Min. 95 Area-%
• Color/Form: White Powder