Product Information
ZL0454 is a small molecule that inhibits the inflammatory response by blocking the interaction between Toll-like receptor 4 and its ligand, lipopolysaccharide. This drug has been shown to have therapeutic potential in chronic viral infections, such as HIV and hepatitis C virus, as well as in inflammatory bowel disease. ZL0454 has also been shown to inhibit coagulation factor activity and has been found to be effective against a variety of cancers including breast, lung, prostate, and colon cancer. ZL0454 binds to bromodomains on histone proteins which are involved in regulating gene expression. This binding prevents acetylation of histones leading to reduced transcriptional activation of genes regulated by these proteins.
ZL0454 also interacts with epithelial mesenchymal transition proteins that regulate cell adhesion and migration.
Chemical properties
Technical inquiry about: 3D-EPD04277 ZL0454
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