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Y16 is a natural compound that was isolated from the leaves of the plant, Ziziphus jujuba. It has been shown to have significant interactions with bacterial cells, specifically inhibiting the growth of E. coli K-12 and P. pastoris by binding to their penicillin-binding protein (PBP). Y16 also inhibits the activities of hydroxylase enzymes in primary cells, such as malonic acid decarboxylase and xanthine oxidase, which are important for postharvest fruit ripening and reactive oxygen species production respectively. Y16 has been shown to inhibit bacterial growth using an x-ray crystal structure analysis on B. subtilis. The anti-microbial activity of this compound may be related to its ability to interfere with bacterial cell membrane permeability.
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