Product Information
Name:Amcasertib (BBI503)
Brand:Biosynth
Description:Amcasertib is a β-catenin inhibitor that inhibits tumor growth and metastasis. It is currently in clinical trials for the treatment of cancer. Amcasertib inhibits the phosphorylation of β-catenin by GSK3β, which leads to its degradation by proteasomes, thereby reducing cellular levels of β-catenin. Amcasertib has also been shown to enhance the cytotoxicity of folfirinox, an anticancer drug. Amcasertib has a hydroxyl group at C-2 and a carbonyl group at C-4, which are necessary for binding to β-catenin. The lack of a disulfide bond makes amcasertib more stable than other potential β-catenin inhibitors.
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Chemical properties
Molecular weight:539.69 g/mol
Formula:C31H33N5O2S
Purity:Min. 95%
Technical inquiry about: Amcasertib (BBI503)
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