6-Amino-2-chloropurine

CAS: 1839-18-5

Ref. 3D-FA08198

Product Information

• Name: 6-Amino-2-chloropurine
• Synonyms: 2-Chloroadenine2-Chloro-6-aminopurine, 1H-Purin-6-amine, 2-chloro-, 2-Chloro-1H-purin-6-amine, 2-Chloro-6-Aminopurine, 2-Chloro-7H-Purin-6-Amine, 2-Chloro-9H-Purin-6-Amine, 2-Chloroadenine(2-Cl-Ade), 2-Chlorophenthiazine, 2-chloro-5H-purin-6-amine, 6-Amino-2-chloro-7H-purine, 6-Amino-2-chloro-9H-purine, 9H-Purin-6-amine, 2-chloro-, Adenine, 2-chloro-, Chloroadenine, NSC 7362, Sq 22982

Description

6-Amino-2-chloropurine (6AC) is a nucleoside analogue that inhibits the synthesis of DNA, RNA, and protein by inhibiting the activity of polymerase chain reaction. It has been used to study the molecular mechanisms of pandemic influenza A virus and HIV infection. 6AC has also been shown to be effective in treating solid tumours and metastatic colorectal cancer in mice. This drug is also used as a competitive inhibitor for measuring endonuclease activity in polymerase chain reactions. 6AC binds to the enzyme's active site and prevents it from cleaving the DNA strands during replication, resulting in incomplete replication of the viral genome.

• Brand: Biosynth

Chemical properties

• Molecular weight: 169.57 g/mol
• Formula: C₅H₄ClN₅
• Purity: Min. 95%
• Color/Form: Powder
• InChI: InChI=1S/C5H4ClN5/c6-5-10-3(7)2-4(11-5)9-1-8-2/h1H,(H3,7,8,9,10,11)
• InChI key: InChIKey=HBJGQJWNMZDFKL-UHFFFAOYSA-N
• SMILES: Nc1nc(Cl)nc2nc[nH]c12