Product Information
Name:R-Afatinib
Brand:Biosynth
Description:Irreversible blocker of three members of the ErbB family (ErbB1, ErbB2/HER2, and ErbB4) with IC50 in nanomolar range. The compound binds covalently to cysteine 797 residue in HER2 and blocks downstream cellular signalling, inhibits cellular growth and promotes apoptosis. Afatinib has been used for the treatment of tyrosine kinase inhibitor-resistant tumours with mutations in ErbB genes, especially for deletions in exon 19 and single nucleotide substitutions in exon 21. It has been used for treatment of non-small cell lung cancer (NSCLC), breast cancer, pancreatic cancer, colorectal cancer, etc.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:485.94 g/mol
Formula:C24H25ClFN5O3
Purity:Min. 95%
Color/Form:White To Off-White Solid
Technical inquiry about: R-Afatinib
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