4-Aminosalicylic acid

CAS: 65-49-6

Ref. 3D-FA10792

Product Information

• Name: 4-Aminosalicylic acid
• Synonyms: 2-Hydroxy-4-aminobenzoic acid, 3-Hydroxy-4-carboxyaniline, 4-Amino-2-hydroxybenzoic acid, 4-Aminosalicylsaure, 4-Asa, 4-Carboxy-3-hydroxyaniline, Acide 4-aminosalicylique, Acido 4-Aminosalicilico, Amino-PAS, Aminosalicylic Acid, Apacil, Apas, Benzoic acid, 4-amino-2-hydroxy-, Deapasil, Entepas, Euteropas, Gabbropas, Granupas, Monopass, Nsc 2083, Nsc 211698, Osacyl, PAS, PAS (acid), Pamacyl, Pamisyl, Para-Pas, Para-aminosalicylic acid, Paramycin, Parasal, Parasalicil, Parasalindon, Pasa, Pasalon, Pasara, Pasem, Paser, Pask, Pasmed, Pasnodia, Pasolac, Propasa, Rezipas, Salicylic acid, 4-amino-, Sanipirol-4, p-Aminosalicylic acid

Description

4-Aminosalicylic acid (4-ASA) is a drug with anti-inflammatory and analgesic properties. It is used in the treatment of bowel disease, including ulcerative colitis and Crohn's disease. 4-ASA binds to the 4th carbon on the para position of p-hydroxybenzoic acid, which is a metabolite of salicylic acid. This binding inhibits the activity of proton pumps that are responsible for maintaining intracellular pH levels in cells. It also prevents the production of inflammatory prostaglandins by inhibiting cyclooxygenase 1 and 2, which are enzymes that catalyze the conversion of arachidonic acid to prostaglandin H2. 4-ASA also has an effect on bacterial infections by interfering with hydrogen bonding interactions between bacterial dna gyrase and dna topoisomerase II, preventing DNA replication. The x-ray crystal structures have demonstrated that 4-ASA

• Brand: Biosynth

Chemical properties

• Molecular weight: 153.14 g/mol
• Formula: C₇H₇NO₃
• Purity: Min. 95%
• Color/Form: Off-White Powder