H-Asp(Gly-OH)-OH

CAS: 3790-52-1

Ref. 3D-FA108000

Product Information

• Name: H-Asp(Gly-OH)-OH
• Synonyms: H-?-Asp-Gly-OH, (S)-2-Amino-4-((carboxymethyl)amino)-4-oxobutanoic acid, <span class="text-smallcaps">L</span>-β-Aspartylglycine, Asparagine, N-(carboxymethyl)-, Asparagine, N-(carboxymethyl)-, <span class="text-smallcaps">L</span>-, Beta-Aspartylglycine, Glycine, <span class="text-smallcaps">L</span>-β-aspartyl-, Glycine, N-<span class="text-smallcaps">L</span>-β-aspartyl-, H-.beta.-Asp-Gly-OH, H-Asp(Gly-Oh)-Oh, L-beta-aspartylglycine, NSC 186908, β-<span class="text-smallcaps">L</span>-Aspartylglycine, β-Aspartylglycine

Description

Polymyxin B is a polycationic antibiotic that has been used in the treatment of infectious diseases and as an ophthalmic ointment. It is effective against bacteria, fungi, and parasites. Polymyxin B exhibits antimicrobial activity by binding to microbial membranes and causing lysis. The redox potential of this antibiotic is low, which can make it difficult for it to penetrate into cells. Oral cephalosporins are acidic drugs that are poorly absorbed from the gastrointestinal tract; they are only active in the distal small intestine and colon. Streptococcus faecalis is a bacterium that causes infections in the upper respiratory tract and urinary tract. Polymyxin B may be used as an oral agent to treat these infections because it does not require acidity for activity. This drug also exhibits anti-inflammatory effects through its ability to inhibit gamma-aminobutyric acid (GABA) synthesis in bowel cells, which leads to decreased inflammation.

• Brand: Biosynth

Chemical properties

• Molecular weight: 190.15 g/mol
• Formula: C₆H₁₀N₂O₅
• Purity: Min. 95%
• InChI: InChI=1S/C6H10N2O5/c7-3(6(12)13)1-4(9)8-2-5(10)11/h3H,1-2,7H2,(H,8,9)(H,10,11)(H,12,13)/t3-/m0/s1
• InChI key: InChIKey=ZTEDWFWBGPKUOD-VKHMYHEASA-N
• SMILES: N[C@@H](CC(=O)NCC(=O)O)C(=O)O