(Asp371)-Tyrosinase (369-377) (human) acetate salt

CAS: 168650-46-2

Ref. 3D-FA109106

Product Information

• Name: (Asp371)-Tyrosinase (369-377) (human) acetate salt
• Synonyms: H-Tyr-Met-Asp-Gly-Thr-Met-Ser-Gln-Val-OH H-YMDGTMSQV-OH
• Brand: Biosynth

Description

Tyrosinase protein:
Peptide Tyrosinase (Asp371) – HLA-A*0201 (YMDGTMSQV) is a human tyrosinase-derived (369-377) peptide by posttranslational conversion of the sequence YMNGTMSQV. Tyrosinase is an oxidase membrane-bound protein. Tyrosinase play a key role in the melanin synthesis pathway. Tyrosinase is presented on the surface of HLA-A*02:01 melanomas and also expressed in melanocytes. Tyrosinase has been still suggested to be a tumor antigen and might be implicated in improvement of immunotherapeutic strategies such as for efficient anticancer vaccine development.
Applications of Peptide Tyrosinase (Asp371) – HLA-A*0201 (YMDGTMSQV):
Peptide Tyrosinase (Asp371) – HLA-A*0201 (YMDGTMSQV) is used to stimulate specific cytotoxic T lymphocytes (CTL) in PBMCs and then to analyze CTL response especially the cytokine production by ELISPOT assay. Peptide Tyrosinase (Asp371) – HLA-A*0201 (YMDGTMSQV) is also involved in experimental therapies of metastatic melanoma by allogeneic hematopoietic stem cell transplantation. In fact, cytotoxic T cells were generated from peripherical blood mononuclear cells (PBMCs) of HLA-A*02:01 healthy donors after being stimulated by injection of Asp371 antigen (2). This strategy raises issues which concern the graft versus tumor (GvT) effect and graft versus host disease (GvHD).

Chemical properties

• Molecular weight: 1,031.16 g/mol
• Formula: C₄₂H₆₆N₁₀O₁₆S₂
• Purity: Min. 95%