(Asp371)-Tyrosinase (369-377) (human) acetate salt

CAS: 168650-46-2

Ref. 3D-FA109106

Product Information

• Name: (Asp371)-Tyrosinase (369-377) (human) acetate salt
• Synonyms: H-Tyr-Met-Asp-Gly-Thr-Met-Ser-Gln-Val-OH H-YMDGTMSQV-OH, [Asp370]-Tyrosinase (368-376), Asp371, Tyrosinase 369-777, Human, Tyr-Met-Asp-Gly-Thr-Met-Ser-Gln-Val, Ymdgtmsqv

Description

Tyrosinase protein:
Peptide Tyrosinase (Asp371) - HLA-A*0201 (YMDGTMSQV) is a human tyrosinase-derived (369-377) peptide by posttranslational conversion of the sequence YMNGTMSQV. Tyrosinase is an oxidase membrane-bound protein. Tyrosinase play a key role in the melanin synthesis pathway. Tyrosinase is presented on the surface of HLA-A*02:01 melanomas and also expressed in melanocytes. Tyrosinase has been still suggested to be a tumor antigen and might be implicated in improvement of immunotherapeutic strategies such as for efficient anticancer vaccine development.
Applications of Peptide Tyrosinase (Asp371) - HLA-A*0201 (YMDGTMSQV):
Peptide Tyrosinase (Asp371) - HLA-A*0201 (YMDGTMSQV) is used to stimulate specific cytotoxic T lymphocytes (CTL) in PBMCs and then to analyze CTL response especially the cytokine production by ELISPOT assay. Peptide Tyrosinase (Asp371) - HLA-A*0201 (YMDGTMSQV) is also involved in experimental therapies of metastatic melanoma by allogeneic hematopoietic stem cell transplantation. In fact, cytotoxic T cells were generated from peripherical blood mononuclear cells (PBMCs) of HLA-A*02:01 healthy donors after being stimulated by injection of Asp371 antigen (2). This strategy raises issues which concern the graft versus tumor (GvT) effect and graft versus host disease (GvHD).

• Brand: Biosynth

Chemical properties

• Molecular weight: 1,031.16 g/mol
• Formula: C₄₂H₆₆N₁₀O₁₆S₂
• Purity: Min. 95%