H-Asn-Arg-Val-Tyr-Val-His-Pro-Phe-OH

CAS: 53-73-6

Ref. 3D-FA109691

Product Information

• Name: H-Asn-Arg-Val-Tyr-Val-His-Pro-Phe-OH
• Synonyms: Angiotensinamide(Asn1,Val5)-Angiotensin II, hypertensin II, 1-amide-5-valyl, asparaginyl-N~5~-(diaminomethylidene)ornithylvalyltyrosylvalylhistidylprolylphenylalanine, L-asparaginyl-N~5~-(diaminomethylidene)-L-ornithyl-L-valyl-L-tyrosyl-L-valyl-L-histidyl-L-prolyl-L-phenylalanine, [1-Asparagine-5-valine]-angiotensin II, 17: PN: WO0144270 SEQID: 20 claimed protein, 18: PN: WO0143761 SEQID: 20 claimed protein, 18: PN: WO0155176 SEQID: 20 claimed protein, 18: PN: WO02087504 SEQID: 20 claimed protein, 19: PN: WO0002905 SEQID: 20 claimed protein, 19: PN: WO0198325 SEQID: 20 claimed protein, 1-Asn2-5-Val-angiotensin II, 1-Asparagine-5-valineangiotensin II, 1-Asparaginyl-5-valyl-angiotensin II, 1-Aspartic acid-5-valine angiotensin II amide, 1-Aspartic acid-β-amide 5-valine angiotensin II, 1-L-Asn-5-L-Val-angiotensin II, 1-L-Asparagine-5-L-valine angiotensin II, 1-L-Asparagine-5-L-valine-angiotensin, 1-L-Asparaginyl-5-L-valyl angiotensin octapeptide, 1-α-Asparagine-5-valine-angiotensin II, 20: PN: US20030130196 SEQID: 20 claimed protein, 24: PN: WO9958140 SEQID: 20 claimed protein, 5-L-Valine-angiotensin II amide, 5-Valine angiotensin amide II, 5-Valine angiotensin II amide, 5-Valine angiotensin II aspartic-β-amide, 5-Valine-angiotensin II-β-amide, 5-Valyl angiotensin II amide, Alanine, N-[1-[N-[N-[N-[N-(N2-L-asparaginyl-L-arginyl)-L-valyl]-L-tyrosyl]-L-valyl]-L-histidyl]-L-prolyl]-3-phenyl-, L-, Angio Tensinamida, Angiotensin (Ciba), Angiotensin amide, Angiotensin amide, 5-L-valine-, Angiotensin II (eel), Angiotensin II (Oncorhynchus mykiss), Angiotensin II amide, Angiotensin II amide 5-valine, Angiotensin II amide, 5-L-valine-, Angiotensin II aspartic-β-amide, 5-L-valine, Angiotensin II, 1-L-asparagine-5-L-valine-, Angiotensin II-5-valine-amide, Angiotensinamid, Hypertensin, Hypertensinamide, Hypertensine, Ipertensina, L-Phenylalanine, N-[1-[N-[N-[N-[N-(N2-L-asparaginyl-L-arginyl)-L-valyl]-L-tyrosyl]-L-valyl]-L-histidyl]-L-prolyl]-, Nsc 107678, Rainbow trout angiotensin II, Val5-angiotensin II amide, Val-Hypertensin-II-asp-β-amide

Description

H-Asn-Arg-Val-Tyr-Val-His-Pro-Phe (HAV) is a small molecule that is a member of the ubiquitin ligase family. This drug has been shown to have a variety of biological effects, including cardiac and bowel disease, as well as hypertension. HAV has also been shown to reduce the risk of heart failure in people with chronic kidney disease. HAV binds to the protein PCSK9 and inhibits its function by binding to the epsilon site on PCSK9. This leads to an increase in low density lipoprotein cholesterol and a decrease in high density lipoprotein cholesterol levels. HAV also has an amide group that allows it to inhibit angiotensin II and act as a pressor agent.

• Brand: Biosynth

Chemical properties

• Molecular weight: 1,031.17 g/mol
• Formula: C₄₉H₇₀N₁₄O₁₁
• Purity: Min. 95%