(D-Arg1,D-Phe5,D-Trp7·9,Leu11)-Substance P

CAS: 96736-12-8

Ref. 3D-FA109992

Product Information

• Name: (D-Arg1,D-Phe5,D-Trp7·9,Leu11)-Substance P
• Synonyms: H-D-Arg-Pro-Lys-Pro-D-Phe-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2 H-(dR)PKP(dF)Q(dW)F(dW)LL-NH2
• Brand: Biosynth
• Description: Substance P is a neuropeptide that binds to the tachykinin receptor NK1. It has potent anti-inflammatory and mitogenic activities, which are mediated through its binding to the NK1 receptor. Substance P can stimulate lung cancer cells to proliferate and inhibit their apoptosis, which may be due to an autocrine mechanism. In addition, it has been shown that substance P can potentiate the growth of some cancers such as colon cancer in vitro and in vivo by increasing DNA synthesis and cell proliferation. This peptide also has a dose-dependent effect on cell growth, with high doses inhibiting cell proliferation at higher levels than low doses.

Chemical properties

• Molecular weight: 1,516.83 g/mol
• Formula: C₇₉H₁₀₉N₁₉O₁₂
• Purity: Min. 95%