Ac-Asp-Glu-Val-Asp-chloromethylketone trifluoroacetate salt

CAS: 285570-60-7

Ref. 3D-FA111126

Product Information

• Name: Ac-Asp-Glu-Val-Asp-chloromethylketone trifluoroacetate salt
• Synonyms: Ac-DEVD-CMK, Caspase-3 Inhibitor III
• Brand: Biosynth
• Description: Ac-Asp-Glu-Val-Asp-chloromethylketone trifluoroacetate salt is a basic protein. It inhibits the neuronal death induced by dopamine and its derivatives, which is caused by overactivation of the mitochondrial membrane potential and release of cytochrome c from mitochondria to cytosol. This compound also inhibits the activation of toll-like receptor 4 (TLR4) and nuclear factor κB (NF-κB) signaling pathways in neuronal cells. Ac-Asp-Glu-Val-Asp-chloromethylketone trifluoroacetate salt has been shown to have antiinflammatory effects when applied topically on skin wounds. The molecule has been used as a model system for studying the molecular mechanism of epidermal growth factor (EGF) activation in hybridoma cell lines and primary cells.

Chemical properties

• Molecular weight: 550.94 g/mol
• Formula: C₂₁H₃₁ClN₄O₁₁
• Purity: Min. 95%