5-Aminovaleric acid

CAS: 660-88-8

Ref. 3D-FA13122

Product Information

• Name: 5-Aminovaleric acid
• Synonyms: 5-Aminopentanoic acidHomopiperidinic acid
• Brand: Biosynth
• Description: 5-Aminovaleric acid is a cyclic peptide that is an antagonist of the enzyme 5-aminovaleric acid hydrolase that catalyzes the conversion of 5-aminovaleric acid to succinic semialdehyde. The physiological function of 5-aminovaleric acid hydrolase is not known, but it has been implicated in a number of neurological disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. The reaction solution contains 5-aminovaleric acid (5AVA), hydrogen fluoride (HF), and l-lysine (Lys). Upon addition of HF to the solution, it reacts with Lys to form a dinucleotide phosphate intermediate. This intermediate then reacts with 5AVA to form an intramolecular hydrogen bond with the amino group of Lys and release hydrogen gas. The detection sensitivity for this reaction can be increased by using a cyclic peptide inhibitor.

Chemical properties

• Molecular weight: 117.15 g/mol
• Formula: C₅H₁₁NO₂
• Purity: Min. 95%
• Color/Form: Off-White Powder
• InChI: InChI=1S/C5H11NO2/c6-4-2-1-3-5(7)8/h1-4,6H2,(H,7,8)
• InChI key: InChIKey=JJMDCOVWQOJGCB-UHFFFAOYSA-N
• SMILES: NCCCCC(=O)O