Product Information
- 7-(Azabenzotriazol-1-yl)oxy tris(dimethylamino)phosphonium hexafluorophosphate
- 7-Azabenzotriazol-1-yloxytris(dimethylamino)phosph
- Tris(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)phosphorus hexafluorophosphate
- 7-Azabenzotriazol-1-yloxytris(dimethyamino) phosphonium hexafluorosphate
- tris(dimethylamino)(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy)phosphonium hexafluorophosphate
AOP is a phosphonium salt and a HOAt derivative employed as a coupling reagent for peptide synthesis. AOP can be used in solution and solid-phase synthesis, is highly efficient with both linear and cyclic peptides, allows to achieve good yields, is a racemisation suppressant and has good reaction rates. AOP is soluble in DMF and requires presence of a base such as Hünig’s base. The drawback of using AOP is the formation of the toxic and carcinogenic by-product HMPA, therefore, it must be handled with care. The pyrrolidino derivative PyAOP is a good alternative to AOP as it achieves comparable performances, but generates a less toxic by-product.
Chemical properties
Technical inquiry about: 3D-FA15661 AOP
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